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surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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BUEES: a bottom-up event extraction system

Xiao DING,Bing QIN,Ting LIU

《信息与电子工程前沿（英文）》 2015年 第16卷 第7期   页码 541-552 doi: 10.1631/FITEE.1400405

摘要： Traditional event extraction systems focus mainly on event type identification and event participant extraction based on pre-specified event type paradigms and manually annotated corpora. However, different domains have different event type paradigms. When transferring to a new domain, we have to build a new event type paradigm and annotate a new corpus from scratch. This kind of conventional event extraction system requires massive human effort, and hence prevents event extraction from being widely applicable. In this paper, we present BUEES, a bottom-up event extraction system, which extracts events from the web in a completely unsupervised way. The system automatically builds an event type paradigm in the input corpus, and then proceeds to extract a large number of instance patterns of these events. Subsequently, the system extracts event arguments according to these patterns. By conducting a series of experiments, we demonstrate the good performance of BUEES and compare it to a state-of-the-art Chinese event extraction system, i.e., a supervised event extraction system. Experimental results show that BUEES performs comparably (5% higher -measure in event type identification and 3% higher -measure in event argument extraction), but without any human effort.

关键词： Event extraction     Unsupervised learning     Bottom-up    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 33-42 doi: 10.1007/s11684-019-0735-3

摘要： Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitors (ICIs) are the most successful agents approved for multiple advanced malignancies. However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems. Up to 90% of patients who received ICIs combination therapy experienced irAEs, of which majority were low-grade toxicity. Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of irAEs. In this review, the mechanisms of action of ICIs and how they may cause irAEs are described. Some unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer treatment response, tumor response to irAEs therapy, and ICIs in challenging populations, are comprehensively summarized.

关键词： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load

Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP

《能源前沿（英文）》 2015年 第9卷 第2期   页码 231-237 doi: 10.1007/s11708-015-0358-6

摘要： The aim of non-intrusive appliance load monitoring (NIALM) is to disaggregate the energy consumption of individual electrical appliances from total power consumption utilizing non-intrusive methods. In this paper, a systematic approach to ON-OFF event detection and clustering analysis for NIALM were presented. From the aggregate power consumption data set, the data are passed through median filtering to reduce noise and prepared for the event detection algorithm. The event detection algorithm is to determine the switching of ON and OFF status of electrical appliances. The goodness-of-fit (GOF) methodology is the event detection algorithm implemented. After event detection, the events detected were paired into ON-OFF pairing appliances. The results from the ON-OFF pairing algorithm were further clustered in groups utilizing the -means clustering analysis. The -means clustering were implemented as an unsupervised learning methodology for the clustering analysis. The novelty of this paper is the determination of the time duration an electrical appliance is turned ON through combination of event detection, ON-OFF pairing and -means clustering. The results of the algorithm implementation were discussed and ideas on future work were also proposed.

关键词： non-intrusive appliance load monitoring     event detection     goodness-of-fit (GOF)     K-means clustering     ON-OFF pairing    

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Discrete-event stochastic systems with correlated inputs: Modeling and performance evaluation

《工程管理前沿（英文）》 2022年 第9卷 第2期   页码 214-220 doi: 10.1007/s42524-022-0192-6

摘要： In the majority of the previous works on discrete-event stochastic systems, they have been assumed to have independent input processes. However, in many applications, these input processes can be highly correlated. Furthermore, the performance measures of the systems with correlated inputs can be significantly different from those with independent inputs. In this paper, we provide an overview on some commonly used methods for modeling correlated input processes, and we discuss the difficulties and possible future research topics in the study of discrete-event stochastic systems with correlated inputs.

关键词： discrete-event stochastic system     correlated input     performance evaluation    

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逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

《中国工程科学》 2003年 第5卷 第11期   页码 47-50

摘要：

采用Fourier谱展开和紧致有限差分格式，选用两组共振三波为相干结构的初值，计算了其在零压和逆压梯度作用下的演化。对演化后期流场的2，4象限的运动进行了详细的分析。结果发现，在逆压梯度下，扫掠对雷诺应力的贡献要强于喷射。无论是在零压梯度还是逆压梯度下，uv和u2在法向的输运主要是靠Q2和Q4这两种运动来完成的。零压梯度下喷射部分对输运的贡献大于扫掠的部分。而在逆压梯度下喷射部分对输运的贡献明显减少，扫掠的作用要强于喷射。

关键词： 相干结构     湍流边界层     逆压梯度     直接数值模拟    

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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

《医学前沿（英文）》 2019年 第13卷 第2期   页码 277-284 doi: 10.1007/s11684-018-0630-3

摘要： The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

关键词： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

《医学前沿（英文）》 doi: 10.1007/s11684-023-1011-0

摘要： We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Thirteen hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30, 2022, were recruited. Laboratory parameters and chest CT (computed tomography) imaging were analyzed. The treatment group included six patients who received 150 mg/100 mg of Paxlovid orally once daily for 5 days, whereas the control group included seven patients who received basic treatment. No serious adverse reactions or safety events were recorded. Four control patients progressed to moderate disease, and none in the treatment group showed progression of chest CT findings (P < 0.05). Paxlovid therapy tended toward early viral clearance and low viral load on Day 8. Moreover, 83.3% of the patients in the treatment group and 57.1% of the patients in the control group turned negative within 22 days. In the Paxlovid treatment group, we found significantly increased levels of lymphocytes (P=0.03) and eosinophils (P=0.02) and decreased levels of D-dimer on Day 8 compared with those on Day 1. Paxlovid therapy showed a potential therapeutic effect with good tolerance in hemodialysis patients. The optimal dose and effectiveness evaluation must be further investigated in a largeer cohort.

关键词： Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

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Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

null

《医学前沿（英文）》 2016年 第10卷 第2期   页码 111-119 doi: 10.1007/s11684-016-0446-y

摘要：

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.

关键词： coronavirus     MERS     Middle East respiratory syndrome    

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Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish

《医学前沿（英文）》 2019年 第13卷 第1期   页码 126-130 doi: 10.1007/s11684-017-0603-y

摘要： Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%–60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic. Of the seven cases, four (57%) patients sought medical advice within 1–7 days from the onset of symptoms. The three other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of breath (14%), vomiting (28%), and diarrhea (28%). Two (28.6%) patients had platelet counts of<150 × 10 /L, and one patient had an underlying end-stage renal disease. The remaining patients presented with normal blood count, liver function, and urea and creatinine levels. The documented MERS-CoV Ct values were 32–38 for four of the seven cases. Two patients (28.6%) had abnormal chest radiographic findings of bilateral infiltration. One patient (14.3%) required ventilator support, and two patients (28.6%) required oxygen supplementation. All the seven patients were discharged without complications.

关键词： Middle East respiratory syndrome coronavirus     MERS-CoV     pregnancy     pediatrics    

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Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 296-301 doi: 10.1007/s11684-012-0219-1

摘要：

Despite the technique of cardiopulmonary bypass (CPB) improved the development of modern cardiac surgery, many factors during CPB have been reported to induce acute respiratory distress syndrome (ARDS). The present study was to investigate which pro-inflammatory factors involved in the early phase of ARDS. Ten patients underwent valve replacement surgery with or without ARDS were enrolled for analysis of pulmonary function and inflammatory factors release including white blood cell (WBC), neutrophils, CD11b, CD18, interleukin (IL)-8 and tumor necrosis factor-α (TNF-α). The results demonstrated that the ratio of arterial oxygen tension/fraction of inspire oxygen (PaO2/FiO2) was greatly reduced in ARDS patients, but only the release of TNF-α was significantly increased, which was reversely correlated to the values of PaO2/FiO2. Also, the count of neutrophils adhesive to pulmonary endothelial cells was significantly increased in ARDS patients. Therefore, we concluded that TNF-α was quickly up-regulated and involved in the pathogenesis of CPB-induced ARDS via guiding primed neutrophils to pulmonary interstitium.

关键词： tumor necrosis factor-α     cardiopulmonary bypass     inflammation     acute respiratory distress syndrome    

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Middle East respiratory syndrome coronavirus: a comprehensive review

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《医学前沿（英文）》 2016年 第10卷 第2期   页码 120-136 doi: 10.1007/s11684-016-0430-6

摘要：

The Middle East respiratory syndrome coronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the Middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to be the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. Here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.

关键词： MERS     coronavirus     review    

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Comparison of reference values for immune recovery between event-free patients receiving haploidentical

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《医学前沿（英文）》 2018年 第12卷 第2期   页码 153-163 doi: 10.1007/s11684-017-0548-1

摘要：

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3+ T cells, CD8+ T cells, and CD19+ B cells, and very slow in CD4+ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.

关键词： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

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浅谈五种宫内节育器不良反应分析

李华洁

《中国工程科学》 2015年 第17卷 第6期   页码 28-30

摘要：

通过观察放置宫内节育器（IUD），爱母环（MCU）、母体乐（MCU375）、宫形环（GCU300）、TCU220C和吉妮环术后不良反应情况，为育龄妇女知情选择IUD提供参考依据。将671例自愿采取放置宫内节育器避孕而无禁忌症的妇女随机分成五组，分别放置A组MCU，B组MCU375，C组GCU300，D组TCU220C，E组吉妮环五种IDU，随访两年，对其术后月经量增多，经期延长，阴道不规则流血，疼痛，脱环，带器妊娠，白带增多情况进行比较。MCU的不良反应较为严重，MCU375和GCU300的不良反应次之，TCU220C和吉妮环不良反应最轻。GCU300的脱环率最高，TCU220C、MCU和MCU375、吉妮环的脱环率都比较低；带器妊娠MCU和GCU300最高，MCU375、TCU220C和吉妮环均低。临床应根据受器者的具体情况选择适当的IUD，提高育龄妇女对避孕措施的满意程度。

关键词： 节育环；不良反应；吉妮环    

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基于矿物异常分析的隧道内不良地质识别方法及案例分析 Article

许振浩, 余腾飞, 林鹏, 李术才

《工程（英文）》 2023年 第27卷 第8期   页码 150-160 doi: 10.1016/j.eng.2022.09.013

摘要： 本研究提出了一种基于矿物异常分析的隧道不良地质识别方法（adverse geology identification through mineral anomaly analysis, AGIMAA），

关键词： 矿物异常     不良地质     断层     蚀变     异常阈值    

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标题 作者 时间 类型 操作

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

null

期刊论文

BUEES: a bottom-up event extraction system

Xiao DING,Bing QIN,Ting LIU

期刊论文

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

期刊论文

A systematic approach to ON-OFF event detection and clustering analysis of non-intrusive appliance load

Chuan Choong YANG,Chit Siang SOH,Vooi Voon YAP

期刊论文

Discrete-event stochastic systems with correlated inputs: Modeling and performance evaluation

期刊论文

逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

期刊论文

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

期刊论文

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

期刊论文

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

null

期刊论文

Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish

期刊论文

Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary

null

期刊论文

Middle East respiratory syndrome coronavirus: a comprehensive review

null

期刊论文

Comparison of reference values for immune recovery between event-free patients receiving haploidentical

null

期刊论文

浅谈五种宫内节育器不良反应分析

李华洁

期刊论文

基于矿物异常分析的隧道内不良地质识别方法及案例分析

许振浩, 余腾飞, 林鹏, 李术才

期刊论文